Can a genome change its (hot)spots?
نویسنده
چکیده
A new study by Jeffreys et al. shows that the rate of recombination in recombination hotspots in humans is not constant through time. This observation adds weight to the idea that hotspots are transient on evolutionary timescales. However, questions remain as to what controls their evolution and how these rapid changes influence broad-scale rates of recombination.
منابع مشابه
Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts
The organization of genomic sequences is dynamic and undergoes change during the process of evolution. Many of the variations arise spontaneously and the observed genomic changes can either be distributed uniformly throughout the genome or be preferentially localized to some regions (hot spots) compared to others. Conversely cold spots may tend to accumulate very few variations or none at all. ...
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ورودعنوان ژورنال:
- Trends in ecology & evolution
دوره 20 12 شماره
صفحات -
تاریخ انتشار 2005